Differentiation between intra- and extra-cellular components of renal "Rb nuclear-magnetic- resonance spectra by lineshape analysis
نویسنده
چکیده
after protein phosphorylation returns to basal levels), the potentiatory effect on 5-HT secretion seems to be selectively 'desensitized' or 'switched-off' with incubation periods > 2 min or > 20 min in stirred and unstirred platelets, respectively, even in the presence of sustained 45 kDa protein phosphorylation. As the time of onset of this process and the inhibition of agonist-induced 5-HT secretion are very similar, we propose that this 'switching-off' of 'proteinkinase-C-dependent' secretion could be responsible for the inhibition of thrombin-induced 'protein-kinase-cdependent' secretion seen with exogenously added protein kinase C activators. 1. Krishnamurthi, S., Joseph, S. & Kakkar, V. V. (1987) Eur. J .
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